Joyce published Ulysses in 1922. Many consider it Joyce's most mature work. It is patterned after Homer's Odyssey. Homer was a Greek poet who produced his works around 850 B.C.E. Each of the eighteen chapters is related to a part of the original Greek epic (long poem that tells a heroic story), but there are other sources, too. The action takes place in a single day, June 16, 1904. It tells the story of Leopold Bloom.

Finnegans Wake is the most difficult of all of Joyce's works to understand. It was published in 1939. The novel has no real plot. Instead, it relies upon sound, rhythm of language, and puns (word jokes). These parts create a surface and the meanings are under that surface. Most people consider Finnegans Wake to be a novel, but others have called it a poem. The novel was not well-received, and Joyce relied on the help of friends for financial assistance after it was published.

Joyce knew his family was not safe in France when it was taken over by the Germans during World War II (1939–45; a war in which Germany, Japan, and Italy fought against France, Great Britain, the Soviet Union, and the United States). He borrowed money and fled to Switzerland with his family. Joyce died in Zurich, Switzerland, on January 13, 1941. He is considered one of the most important novelists of the twentieth century.